Master metabolism with 9 steps:
Here’s my shortcut to remembering it in just
arrows:
Glu → Fru → Pyr
(Glucose → Fructose → Pyruvate)
This is glycolysis — the breakdown of glucose into pyruvate for quick energy.
Example: Eat bread, glucose enters your cells, and is converted to pyruvate to start producing ATP.
Pyr → ACoA → TCA
(Pyruvate → Acetyl-CoA → TCA Cycle)
When oxygen’s available, pyruvate becomes Acetyl-CoA and runs through the TCA (Krebs) cycle for sustained energy.
Example: A post-lunch walk taps into this aerobic pathway.
TCA → NADH → ETC → ATP
(TCA products → NADH → Electron Transport Chain → ATP)
The TCA cycle generates NADH, which powers the electron transport chain to make ATP — your cellular energy currency.
Example: Your brain uses that ATP to keep you sharp while studying.
G6P
PPP → NADPH + Ribose
(Glucose-6-Phosphate → Pentose Phosphate Pathway → NADPH + Ribose)
This detour from glucose creates NADPH (for antioxidant defense) and ribose (for DNA/RNA synthesis).
Example: Immune cells use NADPH to neutralize pathogens.
Pyr → Lac
(Pyruvate → Lactate)
In low-oxygen conditions, pyruvate shifts to lactate.
Pyr → OAA → Gluconeogenesis
(Pyruvate → Oxaloacetate → Glucose)
During fasting, pyruvate is turned into oxaloacetate, then glucose, to maintain blood sugar.
Example: After 10+ hours without food, your liver makes glucose for your brain.
ACoA → FAs → TAGs
(Acetyl-CoA → Fatty Acids → Triglycerides)
Excess energy is stored as fat.
Example: Too many sweets? Your body parks the surplus as belly fat.
FAs → β-ox → ACoA → TCA
(Fatty Acids → Beta-Oxidation → Acetyl-CoA → TCA)
When carbs run low, fat becomes your fuel.
Example: After 14 hours of intermittent fasting, fat breakdown kicks in.
AAs → Pyr / ACoA / TCA
(Amino Acids → Pyruvate or Acetyl-CoA or TCA)
Amino acids can feed into different energy pathways, depending on type.
Example: In prolonged starvation, muscle protein is converted into energy intermediates.
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