The
following truths are based on Solidarity Trial and the Adaptive
COVID-19 Treatment Trial (ACCT1), which was a large trial in the UK and
Europe.
- in the Solidarity Trial, no one benefited from any sub-group.
“Based
on available evidence, there were about five trials... which essentially showed
that Remdesivir given to hospitalised patients, didn’t reduce mortality, it
didn’t reduce the duration of hospitalisation and it didn’t affect the
progression of the disease”. it means it has no efficacy!
As
per Pune doctors, that it is very possible to save patients without
the Remdesivir. They added that it “only reduces hospital stay by two days at
the most.”
plz dont get anxious about Remdesvir.
As
per Solidarity Trial and the Adaptive COVID-19 Treatment Trial (ACCT1), which
was a large trial in the UK and Europe, those who did not need oxygen
(mild disease) also did not benefit, those who got very high oxygen (i.e. they
needed more oxygen support) or ventilators, which means they had a severe
disease, also did not benefit from remdesvir.”
why
because,
“COVID-19
is a fast replicating, respiratory virus - unlike HIV, Hepatitis B or C which
are much slower viruses. Antivirals work in slower replicating viruses because
the build-up takes time so you can block that by antivirals. But in faster
replicating viruses, the ideal time to give the antiviral is before the
symptoms even start and before the virus starts rapidly replicating - if you
can tell the patient has the infection by then.
Hypothetically,
if you could detect that someone has the viral infection without symptoms, that
is the best time for the antiviral to be given for it to work.
“Once
the virus starts replicating there is not much the antiviral can do.
thatswhy you will not need this for “90 per cent of patients.”
Like
in most respiratory diseases, most antivirals do not seem to have any benefit.
Unfortunately
for most viral illnesses, there is no one drug - you do symptomatic treatment.”
COVID-19
has 2 phases:
- Viremia phase: where the virus is in the body
- Acute phase where the immune response creates an issue.
“The
role of steroids is usually when our immune response is causing a problem, and
here those on oxygen and ventilators benefit the most.
“Because
steroids are so successful, everyone is prescribing steroids the day COVID-19
is detected and that is actually causing a big problem. It is prolonging the
viremia and suppressing the immune response when at that phase, it is
necessary.
The
immune response is a necessary evil, and we need a balanced one for COVID-19 -
one that attacks the virus well but not our body. ”
Now
if steroids are needed, doctors were administering Remdesivir. “But given the
studies, the role of Remdesivir becomes questionable.”
Rational use of Remdesivir in COVID 19 and prevention of its misuse "
1. Remdesivir is an experimental investigational drug granted Emergency use authorisation for use in
2. Remdesivir is not a life-saving drug in COVID -19; studies do not demonstrate mortality reduction with this drug
3. Evidence shows Remdesivir reduces the duration of hospital stay
4. Remdesivir is to be administered only, and only, in the hospital setting
5. Remdesivir is advised for hospitalized patients who are moderately sick and receiving oxygen. It is to be given for a total period of 5 days only, during the first 9-10 days of the illness
6. Remdesivir must never be administered in the home setting
7. Unnecessary / irrational use of Remdesivir is unethical.
Comments
Post a Comment