learning points:
COVID-19 is a multiphasic disease starting with virus replicative phase lasting for 7-10 days, subsequently, in some patients,which is followed with hyper inflammatory phase and cytokine storm where most of the fatalities are likely to occur 4 .
If the viral and hyper inflammatory phases of the disease were not addressed early and properly, the patient might progress to ARDS. which is more often life-threatening 5 . Hence, antiviral, anti-inflammatory, and immunomodulatory medications are necessary to stop the vicious progression of COVID-19 from mild-moderate to severe and to prevent the clinical deterioration in COVID-19 infected patients
Doxycycline based combination treatment was used in this study have demonstrated dual - antiviral and immunomodulatory activities 6 . Also, noteworthy is that Doxycycline is a broad-spectrum antibiotic which tackles secondary bacterial infections in COVID-19 patients .
what is the regimen?
Doxycycline 100mg PO every 12h per day was given for 5-10 days, based on the clinical improvement of patients. Ivermectin 200ug/kg PO per day was administered for two days, and in some patients, who needed more time to recover, a third dose 200ug/kg PO per day was given 7 days after the first dose
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