The enteric nervous system: a second brain AND NOW,THE RESEARCH Reveals that our skin is acting as 3rd.Brain.
There is extensive evidence that multiple sensory systems are functionally expressed in epidermal keratinocytes, together with a range of neurotransmitters and their receptors.
Epidermal keratinocytes also secrete multiple bioactive molecules with the potential to influence whole-body physiology and emotional state. Thus, the epidermis appears to have the functional systems required for reception of environmental information from sensory organs, processing of that information, and transmission of it to the systems of the whole body.
In other words, the epidermis, like the brain, has the capability to act as an interface between the body and the environment .
Although much further research is needed to validate the idea that the epidermis serves as a “third brain”, this concept is an exciting one, opening up new vistas for the treatment of skin diseases and for our understanding of whole-body homeostasis.
There is extensive evidence that multiple sensory systems are functionally expressed in epidermal keratinocytes, together with a range of neurotransmitters and their receptors.
Epidermal keratinocytes also secrete multiple bioactive molecules with the potential to influence whole-body physiology and emotional state. Thus, the epidermis appears to have the functional systems required for reception of environmental information from sensory organs, processing of that information, and transmission of it to the systems of the whole body.
In other words, the epidermis, like the brain, has the capability to act as an interface between the body and the environment .
Although much further research is needed to validate the idea that the epidermis serves as a “third brain”, this concept is an exciting one, opening up new vistas for the treatment of skin diseases and for our understanding of whole-body homeostasis.
epidermal keratinocytes. Epidermal keratinocytes can sense a variety of environmental factors and stimuli. This information could be processed in the epidermis and passed via the nervous system to the whole body and brain. TRP = transient receptor potential family of receptors.
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